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Mechanics of Cancer Cells in 3D Microenvironments


Abstract Mechanical properties (e.g. deformability or stiffness) are critical to a cancer cell's ability to maneuver through and exert forces upon the extracellular matrix, and thus affect its ability to metastasize. §3.1 introduces the experimental method combining atomic force microscope (AFM) based indentation and confocal laser scanning microscopy (CLSM). §3.2 presents a method combining AFM and confocal microscopy (AFM stiffness nanotomography), and results on normal and pre-cancerous esophageal cells which indicate that even in the earliest stages, cancer cells exhibit increased deformability. §3.3 presents experimental results on weakly metastatic breast cancer cells that compare well with values obtained from other experimental methods ... (more)
Created Date 2014
Contributor Staunton, Jack Rory (Author) / Ros, Robert (Advisor) / Lindsay, Stuart M. (Committee member) / Davies, Paul C. W. (Committee member) / Vaiana, Sara M. (Committee member) / Arizona State University (Publisher)
Subject Biophysics / Mechanics / Cellular biology / Cancer / Extracellular Matrix / Invasion / Metastasis / Microenvironment / Stiffness
Type Doctoral Dissertation
Extent 215 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Physics 2014
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis