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Studying Biomolecular Structures and Their Interaction Using Atomic Force Microscopy


Abstract Atomic force microscopy (AFM) has become an important tool to characterize and image surfaces with nanoscale resolution. AFM imaging technique has been utilized to study a wide range of substances such as DNA, proteins, cells, silicon surfaces, nanowires etc. Hence AFM has become extremely important in the field of biochemistry, cell biology and material science. Functionalizing the AFM tip made it possible to detect molecules and their interaction using recognition imaging at single molecule level. Also the unbinding force of two molecules can be investigated based on AFM based single molecule force spectroscopy.

In the first study, a new chemical approach to functionalize the AFM tip in a simple and user-friendly way has been described. ... (more)
Created Date 2015
Contributor SENAPATI, SUBHADIP (Author) / Lindsay, Stuart (Advisor) / Zhang, Peiming (Advisor) / Ghirlanda, Giovanna (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Nanoscience / Biochemistry
Type Doctoral Dissertation
Extent 133 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis