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Ion Flux Regulates Inflammasome Signaling

Abstract The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is essential for the innate immune response to danger signals. Importantly, the NLRP3 inflammasome responds to structurally and functionally dissimilar stimuli. It is currently unknown how the NLRP3 inflammasome responds to such diverse triggers. This dissertation investigates the role of ion flux in regulating the NLRP3 inflammasome. Project 1 explores the relationship between potassium efflux and Syk tyrosine kinase. The results reveal that Syk activity is upstream of mitochondrial oxidative signaling and is crucial for inflammasome assembly, pro-inflammatory cytokine processing, and caspase-1-dependent pyroptotic cell death. Dynamic potassium imaging and molecular analysis re... (more)
Created Date 2015
Contributor Yaron, Jordan Robin (Author) / Meldrum, Deirdre R (Advisor) / Blattman, Joseph N (Committee member) / Glenn, Honor L (Committee member) / Arizona State University (Publisher)
Subject Cellular biology / Immunology / Biology / Cell Biology / Cell Death / Immunology / Inflammasome / Inflammation / Macrophage
Type Doctoral Dissertation
Extent 126 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Biological Design 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis