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Structure-Function Study of Telomerase RNA from Evolutionary Disparate Species: Remarkable Divergence in Gross Architecture with the Preservation of Critical Universal Structural Elements


Abstract Telomerase enzyme is a truly remarkable enzyme specialized for the addition of short, highly repetitive DNA sequences onto linear eukaryotic chromosome ends. The telomerase enzyme functions as a ribonucleoprotein, minimally composed of the highly conserved catalytic telomerase reverse transcriptase and essential telomerase RNA component containing an internalized short template region within the vastly larger non-coding RNA. Even among closely related groups of species, telomerase RNA is astonishingly divergent in sequence, length, and secondary structure. This massive disparity is highly prohibitive for telomerase RNA identification from previously unexplored groups of species, which is fundamental for secondary structure determination.... (more)
Created Date 2015
Contributor Podlevsky, Joshua David (Author) / Chen, Julian (Advisor) / Mangone, Marco (Committee member) / Kusumi, Kenro (Committee member) / Wilson-Rawls, Norma (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / Biochemistry / bioinformatics / echinoderm / secondary structure / telomerase reverse transcriptase / telomerase RNA / Trypanosoma
Type Doctoral Dissertation
Extent 302 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Molecular and Cellular Biology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis