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Mu-Opioid Receptor - pAKT Signaling in the Ventral Tegmental Area is Critical for the Behavioral and Cellular Consequences of Social Stress


Abstract Intermittent social defeat stress produces vulnerability to drugs of abuse, a phenomena known as cross-sensitization, which is proceeded by a corresponding upregulation of ventral tegmental area (VTA) mu-opioid receptors (MORs). Since VTA MORs are implicated in the expression of psychostimulant sensitization, they may also mediate social stress-induced vulnerability to drugs of abuse. Social stress and drugs of abuse increase mesolimbic brain-derived neurotrophic factor (BDNF) signaling with its receptor, tropomyosin-related kinase B (TrkB). These studies examined whether VTA MOR signaling is important for the behavioral and cellular consequences of social stress. First, the function of VTA MORs in the behavioral consequences of intermitten... (more)
Created Date 2015
Contributor Johnston, Caitlin Elizabeth (Author) / Hammer, Ronald P. (Advisor) / Nikulina, Ella M. (Advisor) / Neisewander, Janet L. (Committee member) / Wu, Jie (Committee member) / Olive, Michael F. (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Molecular biology / Psychology / AKT / amphetamine / BDNF / mu-opioid receptor / sensitization / stress
Type Doctoral Dissertation
Extent 188 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Neuroscience 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis