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Cancer Autoantibody Biomarker Discovery and Validation Using Nucleic Acid Programmable Protein Array


Abstract Currently in the US, many patients with cancer do not benefit from the population-based screening, due to challenges associated with the existing cancer screening scheme. Blood-based diagnostic assays have the potential to detect diseases in a non-invasive way. Proteins released from small early tumors may only be present intermittently and get diluted to tiny concentrations in the blood, making them difficult to use as biomarkers. However, they can induce autoantibody (AAb) responses, which can amplify the signal and persist in the blood even if the antigen is gone. Circulating autoantibodies is a promising class of molecules that have potential to serve as early detection biomarkers for cancers. This Ph.D thesis aims to screen for autoant... (more)
Created Date 2015
Contributor Wang, Jie (Author) / LaBaer, Joshua (Advisor) / Anderson, Karen S (Committee member) / Lake, Douglas F (Committee member) / Chang, Yung (Committee member) / Arizona State University (Publisher)
Subject Biology / Engineering / Biomarker / Cancer / Early Detection / Protein array
Type Doctoral Dissertation
Extent 192 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Biological Design 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis