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Characterizing the Molecular Genetic, Phenotypic and Virulence Properties of the Invasive Nontyphoidal Salmonella Strain D23580: An Integrated Approach


Abstract Invasive salmonellosis caused by Salmonella enterica serovar Typhimurium ST313 is a major health crisis in sub-Saharan Africa, with multidrug resistance and atypical clinical presentation challenging current treatment regimens and resulting in high mortality. Moreover, the increased risk of spreading ST313 pathovars worldwide is of major concern, given global public transportation networks and increased populations of immunocompromised individuals (as a result of HIV infection, drug use, cancer therapy, aging, etc). While it is unclear as to how Salmonella ST313 strains cause invasive disease in humans, it is intriguing that the genomic profile of some of these pathovars indicates key differences between classic Typhimurium (broad host rang... (more)
Created Date 2015
Contributor Yang, Jiseon (Author) / Nickerson, Cheryl A. (Advisor) / Chang, Yung (Committee member) / Stout, Valerie (Committee member) / Ott, C Mark (Committee member) / Roland, Kenneth (Committee member) / Barrila, Jennifer (Committee member) / Arizona State University (Publisher)
Subject Microbiology / Molecular biology / Biophysics / colonization / fluid-shear / pathogenesis/virulence / Salmonella ST313 / transcriptomics
Type Doctoral Dissertation
Extent 170 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Microbiology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis