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Insights Towards Developing Regenerative Therapies: The Lizard, <i>Anolis carolinensis</i>, as a Genetic Model for Regeneration in Amniotes


Abstract Damage to the central nervous system due to spinal cord or traumatic brain injury, as well as degenerative musculoskeletal disorders such as arthritis, drastically impact the quality of life. Regeneration of complex structures is quite limited in mammals, though other vertebrates possess this ability. Lizards are the most closely related organism to humans that can regenerate de novo skeletal muscle, hyaline cartilage, spinal cord, vasculature, and skin. Progress in studying the cellular and molecular mechanisms of lizard regeneration has previously been limited by a lack of genomic resources. Building on the release of the genome of the green anole, <i>Anolis carolinensis</i>, we developed a second generation, robust RNA-Seq-ba... (more)
Created Date 2015
Contributor Hutchins, Elizabeth (Author) / Kusumi, Kenro (Advisor) / Rawls, Jeffrey A. (Committee member) / DeNardo, Dale F. (Committee member) / Huentelman, Matthew J. (Committee member) / Arizona State University (Publisher)
Subject Genetics / Bioinformatics / Developmental biology / Anolis carolinensis / lizard / microRNA / regeneration / RNA-Seq / transcriptome
Type Doctoral Dissertation
Extent 127 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Molecular and Cellular Biology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis