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Isolation and Functional Studies of The F-type ATP Synthase from Spinach Chloroplasts and Heliobacterium modesticaldum

Abstract Adenosine triphosphate (ATP) is the universal chemical energy currency in most living cells, used to power many cellular reactions and generated by an enzyme supercomplex known as the ATP synthase, consisting of a hydrophilic F1 subcomplex and a membrane-bound FO subcomplex. Driven by the electrochemical gradient generated by the respiratory or photosynthetic electron transport chain, the rotation of the FO domain drives movements of the central stalk in response to conformational changes in the F1 domain, in which the physical energy is converted into chemical energy through the condensation of ADP and Pi to ATP. The exact mechanism how ATP synthesis is coupled to proton translocation is not known as no structure of the intact ATP-synthase... (more)
Created Date 2015
Contributor Yang, Jay-How (Author) / Fromme, Petra (Advisor) / Redding, Kevin (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Subject Biochemistry / ATP synthase
Type Doctoral Dissertation
Extent 219 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Biochemistry 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis