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The Epigenome: Possible Mechanisms by which Early Life Stress May Prime Vulnerability towards Substance Use Disorder

Abstract Evidence from the 20th century demonstrated that early life stress (ELS) produces long lasting neuroendocrine and behavioral effects related to an increased vulnerability towards psychiatric illnesses such as major depressive disorder, post-traumatic stress disorder, schizophrenia, and substance use disorder. Substance use disorders (SUDs) are complex neurological and behavioral psychiatric illnesses. The development, maintenance, and relapse of SUDs involve multiple brain systems and are affected by many variables, including socio-economic and genetic factors. Pre-clinical studies demonstrate that ELS affects many of the same systems, such as the reward circuitry and executive function involved with addiction-like behaviors. Previous resea... (more)
Created Date 2015
Contributor Lewis, Candace R (Author) / Olive, M. Foster (Advisor) / Hammer, Ronald (Committee member) / Neisewander, Janet (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Psychobiology / Behavioral sciences / early life stress / epigenetics / maternal separation / mecp2 / methamphetamine / self administration
Type Doctoral Dissertation
Extent 187 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Psychology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis