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Synthesis and Evaluation of Multifunctional Radical Quenchers for the Protection of Mitochondrial Function


Abstract Mitochondria produce the majority portion of ATP required in eukaryotic cells. ATP is generated through a process known as oxidative phosphorylation, through an pathway consisting five multi subunit proteins (complex I-IV and ATP synthase), embedded inside the mitochondrial membrane. Mitochondrial electron transport chain dysfunction increases reactive oxygen species in the cell and causes several serious disorders. Described herein are the synthesis of antioxidant molecules to reduce the effects in an already dysfunctional system. Also described is the study of the mitochondrial electron transport chain to understand the mechanism of action of a library of antioxidants. Illustrated in chapter 1 is the general history of research on mitocho... (more)
Created Date 2015
Contributor Dey, Sriloy (Author) / Hecht, Sidney M (Advisor) / Angell, Charles A (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Organic chemistry / Electron transport chain / Mitochondria / Mitochondrial drug / MRQ / Organic chemistry / Synthesis
Type Doctoral Dissertation
Extent 197 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis