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Engineering Three Dimensional Cardiac Micro-Tissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts


Abstract Cardiac tissue engineering has major applications in regenerative medicine, disease modeling and fundamental biological studies. Despite the significance, numerous questions still need to be explored to enhance the functionalities of the engineered tissue substitutes. In this study, three dimensional (3D) cardiac micro-tissues were developed through encapsulating co-culture of cardiomyocytes and cardiac fibroblasts, as the main cellular components of native myocardium, within photocrosslinkable gelatin-based hydrogels. Different co-culture ratios were assessed to optimize the functional properties of constructs. The geometry of the micro-tissues was precisely controlled using micro-patterning techniques in order to evaluate their role on sy... (more)
Created Date 2015
Contributor Saini, Harpinder (Author) / Nikkhah, Mehdi (Advisor) / Vernon, Brent (Committee member) / Towe, Bruce (Committee member) / Arizona State University (Publisher)
Subject Engineering / Biomedical engineering
Type Masters Thesis
Extent 117 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Masters Thesis Bioengineering 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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