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Insulator-Based Dielectrophoretic Manipulation of DNA in a Microfluidic Device


Abstract DNA and DNA nanoassemblies such as DNA origamis have large potential in biosensing, drug delivery, nanoelectronic circuits, and biological computing requiring suitable methods for migration and precise positioning. Insulator-based dielectrophoresis (iDEP) provides an efficient and matrix-free approach for manipulation of micro-and nanometer-sized objects. In order to exploit iDEP for naturally formed DNA and DNA nanoassemblies, a detailed understanding of the underlying polarization and dielectrophoretic migration is essential. The shape and the counterion distribution are considered two essential factors in the polarization mechanism. Here, the dielectrophoretic behavior of 6-helix bundle (6HxB) and triangle DNA origamis with identical seq... (more)
Created Date 2015
Contributor Gan, Lin (Author) / Ros, Alexandra (Advisor) / Buttry, Daniel (Committee member) / Liu, Yan (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Analytical chemistry / Dielectrophoresis / DNA / DNA origami / Microfluidics
Type Doctoral Dissertation
Extent 128 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis
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Description Presentation for Lin Gan's thesis defense (orginally in pptx exported in PDF)