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Identification of Structural Mechanisms that Modulate Glycosaminoglycan Affinity in Various Strains of Decorin Binding Protein A


Abstract Glycosaminoglycans (GAGs) are a class of complex biomolecules comprised of linear, sulfated polysaccharides whose presence on cell surfaces and in the extracellular matrix involve them in many physiological phenomena as well as in interactions with pathogenic microbes. Decorin binding protein A (DBPA), a Borrelia surface lipoprotein involved in the infectivity of Lyme disease, is responsible for binding GAGs found on decorin, a small proteoglycan present in the extracellular matrix. Different DBPA strains have notable sequence heterogeneity that results in varying levels of GAG-binding affinity. In this dissertation, the structures and GAG-binding mechanisms for three strains of DBPA (B31 and N40 DBPAs from B. burgdorferi and PBr DBPA from ... (more)
Created Date 2015
Contributor Morgan, Ashli (Author) / Wang, Xu (Advisor) / Allen, James (Committee member) / Yarger, Jeffery (Committee member) / Arizona State University (Publisher)
Subject Biochemistry / Biophysics / Chemistry / Decorin Binding Protein / Glycosaminoglycan / Glycosaminoglycan-binding protein / Lyme disease / NMR (nuclear magnetic resonance)
Type Doctoral Dissertation
Extent 151 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Biochemistry 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis