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The Effect of Vitamin D Supplementation on Plasma Aβ in an Older Population: A Randomized Control Trial


Abstract Vitamin D deficiency has been previously associated with a higher Alzheimer’s disease (AD) risk, a condition marked by dependent living and severe cognitive impairment. AD is histologically defined by the presence of brain amyloid beta (Aβ) plaques and neurofibrillary tangles. Ways to enhance Aβ clearance have been examined in order to sustain cognition and delay AD onset. In vitro and in vivo studies suggest that vitamin D might enhance brain Aβ transportation to the periphery by up-regulating P-glycoprotein production. The purpose of this study was to examine the effect of vitamin D supplementation on plasma Aβ in an older population.

This study was a parallel-arm, double-blinded, randomized control trial. Participants consumed either ... (more)
Created Date 2015
Contributor Miller, Brendan Joseph (Author) / Johnston, Carol (Advisor) / Whisner, Corrie (Committee member) / Tasevska, Natasha (Committee member) / Arizona State University (Publisher)
Subject Nutrition / Neurosciences / Alzheimer's disease / Amyloid beta / Dementia / Vitamin D
Type Masters Thesis
Extent 130 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Masters Thesis Nutrition 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis