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Caveolin-1: A Potential Biomarker of Aggressive Triple-Negative Breast Cancer in African American Women


Abstract In the U.S., breast cancer (BC) incidences among African American (AA) and CA (CA) women are similar, yet AA women have a significantly higher mortality rate. In addition, AA women often present with tumors at a younger age, with a higher tumor grade/stage and are more likely to be diagnosed with the highly aggressive triple-negative breast cancer (TNBC) subtype. Even within the TNBC subtype, AA women have a worse clinical outcome compared to CA. Although multiple socio-economic and lifestyle factors may contribute to these observed health disparities, it is essential that the underlying biological differences between CA and AA TNBC are identified. In this study, gene expression profiling was performed on archived FFPE samples, obtained fro... (more)
Created Date 2015
Contributor Getz, Julie Elizabeth (Author) / Baumbach-Reardon, Lisa L (Advisor) / Lake, Douglas F (Advisor) / Bussey, Kimberly (Committee member) / Kusumi, Kenro (Committee member) / Arizona State University (Publisher)
Subject Molecular biology / African American / Caucasian / Caveolin-1 / Health Disparities / Race / Triple-Negative Breast Cancer
Type Doctoral Dissertation
Extent 78 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Molecular and Cellular Biology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis