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Engineering a Three Dimensional Micropatterned Tumor Model for Breast Cancer Cell Migration Studies


Abstract Breast cancer cell invasion is a highly orchestrated process driven by a myriad of complex microenvironmental stimuli. These complexities make it difficult to isolate and assess the effects of specific parameters including matrix stiffness and tumor architecture on disease progression. In this regard, morphologically accurate tumor models are becoming instrumental to perform fundamental studies on cancer cell invasion within well-controlled conditions. In this study, the use of photocrosslinkable hydrogels and a novel, two-step photolithography technique was explored to microengineer a 3D breast tumor model. The microfabrication process presented herein enabled precise localization of the cells and creation of high stiffness constructs adja... (more)
Created Date 2015
Contributor Sam, Feba (Author) / Nikkhah, Mehdi (Advisor) / Ros, Robert (Committee member) / Smith, Barbara (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / Breast cancer / Gelatin methacrylate (GelMA) / MCF7 / MDA-MB-231 / Micropatterning / Tumor model
Type Masters Thesis
Extent 87 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Masters Thesis Bioengineering 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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