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Cognitive Changes Across the Menopause Transition: A Longitudinal Evaluation of the Impact of Age and Ovarian Status on Spatial Memory

Abstract Aging and the menopause transition are both intricately linked to cognitive changes

during mid-life and beyond. Clinical literature suggests the age at menopause onset can differentially impact cognitive status later in life. Yet, little is known about the relationship between behavioral and brain changes that occur during the transitional stage into the post-menopausal state. Much of the pre-clinical work evaluating an animal model of menopause involves ovariectomy in rodents; however, ovariectomy results in an abrupt loss of circulating hormones and ovarian tissue, limiting the ability to evaluate gradual follicular depletion. The 4-vinylcyclohexene diepoxide (VCD) model simulates transitional menopause in rodents by selectively depletin... (more)
Created Date 2015
Contributor Koebele, Stephanie Victoria (Author) / Bimonte-Nelson, Heather A (Advisor) / Aiken, Leona S (Committee member) / Conrad, Cheryl D (Committee member) / Wynne, Clive DL (Committee member) / Arizona State University (Publisher)
Subject Psychology / Behavioral psychology / Neurosciences / Aging / Cognition / Hormones / Memory / Menopause / Rat
Type Masters Thesis
Extent 84 pages
Language English
Reuse Permissions All Rights Reserved
Note Masters Thesis Psychology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis