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Migration for Organelles and Bacteria in Insulator-Based Microfluidic Devices


Abstract Efficient separation techniques for organelles and bacteria in the micron- and sub-micron range are required for various analytical challenges. Mitochondria have a wide size range resulting from the sub-populations, some of which may be associated with diseases or aging. However, traditional methods can often not resolve within-species size variations. Strategies to separate mitochondrial sub-populations by size are thus needed to study the importance of this organelle in cellular functions. Additionally, challenges also exist in distinguishing the sub-populations of bio-species which differ in the surface charge while possessing similar size, such as Salmonella typhimurium (Salmonella). The surface charge of Salmonella wild-type is altered... (more)
Created Date 2015
Contributor Luo, Jinghui (Author) / Ros, Alexandra (Advisor) / Hayes, Mark (Committee member) / Borges, Chad (Committee member) / Arizona State University (Publisher)
Subject Analytical chemistry / Chemistry / Biochemistry / absolute negative mobility / deterministic / dielectrophoresis / insulator-based / microfluidic / separation
Type Doctoral Dissertation
Extent 137 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Biochemistry 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis