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Small Molecule Inhibition of Quiescin Sulfhydryl Oxidase 1 (QSOX1), a Dynamic Pro-Tumorigenic Regulator of the Extracellular Matrix


Abstract Quiescin sulfhydryl oxidase 1 (QSOX1) is a highly conserved disulfide bond-generating enzyme that represents the ancient fusion of two major thiol-disulfide oxidoreductase gene families: thioredoxin and ERV. QSOX1 was first linked with cancer after being identified as overexpressed in pancreatic ductal adenocarcinoma (but not in adjacent normal ductal epithelia, infiltrating lymphocytes, or chronic pancreatitis). QSOX1 overexpression has been confirmed in a number of other histological tumor types, such as breast, lung, kidney, prostate, and others. Expression of QSOX1 supports a proliferative and invasive phenotype in tumor cells, and its enzymatic activity is critical for promoting an invasive phenotype. An in vivo tumor growth study util... (more)
Created Date 2015
Contributor Hanavan, Paul Daniel (Author) / Lake, Douglas (Advisor) / LaBaer, Joshua (Committee member) / Mangone, Marco (Committee member) / Borges, Chad (Committee member) / Arizona State University (Publisher)
Subject Cellular biology / Molecular biology / Biochemistry / Cancer / Invasion / LOPAC1280 / QSOX1 / Small molecule inhibition / Xenograft
Type Doctoral Dissertation
Extent 103 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Molecular and Cellular Biology 2015
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis