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Synthesis of Methylene Blue Analogues as Multifunctional Radical Quenchers, Synthesis of Unnatural Amino Acids and Their Ribosomal Incorporation into Proteins

Abstract The energy required in a eukaryotic cell is provided by mitochondria. Mitochondrial electron transport chain (ETC) coupled with oxidative phosphorylation generates ATP. During electron transport, electron leakage from the ETC produces reactive oxygen species (ROS). In healthy cells, there are preventive and defense mechanisms in place to manage ROS. Maintaining a steady balance of ROS is very important because overproduction of ROS can lead to several pathological conditions. There are several strategies to prevent ROS production. Addition of external antioxidants is widely used among them. Discussed in the first part of Chapter 1 is the mitochondrial ETC, ROS production and antioxidant strategies.

The second part of Chapter 1 is ... (more)
Created Date 2016
Contributor Roy Chowdhury, Sandipan (Author) / Hecht, Sidney (Advisor) / Gould, Ian (Committee member) / Gust, John Devens (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Biochemistry / Medicine / Antioxidant / Beta amino acid / Green fluorescent protein / In vitro protein synthesis / Methylene blue / Methylene violet
Type Doctoral Dissertation
Extent 159 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis