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Factors that modulate production of tryptophan by Gut Bacteria

Abstract Microorganisms can produce metabolites in the gut including short chain fatty acids, vitamins, and amino acids. Certain metabolites produced in the gut can affect the brain through changes in neurotransmitter concentrations. Serotonin, a neurotransmitter, is associated with mood, appetite, and sleep. Up to 90% of serotonin synthesis is located in the gut, by human enterochromaffin cells. Bacteria known to biosynthesize tryptophan, precursor to serotonin, include Escherichia coli, Enterococcus and Streptococcus. Tryptophan is synthesized by bacteria with the enzyme tryptophan synthase and requires Vitamin B6 (Pyridoxal). We hypothesize that gut isolates from surgical weight loss patients can enhance tryptophan production, which relies o... (more)
Created Date 2016-05
Contributor Yee, Emily L. (Author) / Krajmalnik-Brown, Rosa (Thesis Director) / Ilhan, Zehra (Committee Member) / W. P. Carey School of Business / School of Life Sciences / Barrett, The Honors College
Subject Tryptophan / Serotonin / Microbiota
Series Academic Year 2015-2016
Type Text
Extent 24 pages
Language English
Reuse Permissions All Rights Reserved
Collaborating Institutions Barrett, the Honors College
Additional Formats MODS / OAI Dublin Core / RIS

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