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A Comparison of the Impact of Temperature and Glucose Concentration on Percent Glycated Serum Albumin between Chickens and Humans


Abstract The glycation of plasma proteins leading to the production of advanced glycation end products (AGEs) and subsequent damage is a driving factor in the pathophysiology of diabetic complications. The overall research objective was to elucidate the mechanisms by which birds prevent protein glycation in the presence of naturally high plasma glucose concentrations. This was accomplished through the specific purpose of examining the impact of temperature and glucose concentration on the percent glycation of chicken serum albumin (CSA) in comparison to human serum albumin (HSA). Purified CSA and HSA solutions prepared at four different glucose concentrations (0 mM, 5.56 mM, 11.11 mM, and 22.22 mM) were incubated at three different temperatures (37.... (more)
Created Date 2016
Contributor Zuck, Jessica Ann (Author) / Sweazea, Karen (Advisor) / Johnston, Carol (Committee member) / Lespron, Christy (Committee member) / Arizona State University (Publisher)
Subject Nutrition / Physiology / AGEs / Albumin / Diabetes / Glycation
Type Masters Thesis
Extent 77 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Masters Thesis Nutrition 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis