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A Vaccine to Close the Window of Opportunity for Measles Infection

Abstract Despite the safe and effective use of attenuated vaccines for over fifty years, measles virus (MV) remains an insidious threat to global health. Problematically, infants less than one year of age, who are the most prone to severe infection and death by measles, cannot be immunized using current MV vaccines. For this dissertation, I generated and performed preclinical evaluation of two novel MV vaccine candidates. Based on data from clinical trials that showed increasing the dosage of current MV vaccines improved antibody responses in six-month-old recipients, I hypothesized that increasing the relevant antigenic stimulus of a standard titer dose would allow safe and effective immunization at a younger age. I generated two modified MVs with ... (more)
Created Date 2016
Contributor Julik, Emily (Author) / Reyes del Valle, Jorge (Advisor) / Chang, Yung (Committee member) / Blattman, Joseph (Committee member) / Hogue, Brenda (Committee member) / Nickerson, Cheryl (Committee member) / Arizona State University (Publisher)
Subject Virology / Molecular biology / Hemagglutinin / Measles / Recombinant vaccine / Viral vectors / Young infants
Type Doctoral Dissertation
Extent 120 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Molecular and Cellular Biology 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis