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Oncolytic Viral and Immunotherapy Models Combined with Strategies to Ameliorate Cancer Burden


Abstract Combination therapy has shown to improve success for cancer treatment. Oncolytic virotherapy is cancer treatment that uses engineered viruses to specifically infect and kill cancer cells, without harming healthy cells. Immunotherapy boosts the body's natural defenses towards cancer. The combination of oncolytic virotherapy and immunotherapy is explored through deterministic systems of nonlinear differential equations, constructed to match experimental data for murine melanoma. Mathematical analysis was done in order to gain insight on the relationship between cancer, viruses and immune response. One extension of the model focuses on clinical needs, with the underlying goal to seek optimal treatment regimens; for both frequency and dose... (more)
Created Date 2016
Contributor Summer, Ilyssa (Author) / Castillo-Chavez, Carlos (Advisor) / Nagy, John (Advisor) / Mubayi, Anuj (Committee member) / Kang, Yun (Committee member) / Arizona State University (Publisher)
Subject Applied mathematics / Oncology / Combination Treatment / Dendritic Cell Vaccine / Immunotherapy / Numerical analysis / Oncolytic Virus / Ordinary Differential Equations
Type Doctoral Dissertation
Extent 127 pages
Language English
Copyright
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Note Doctoral Dissertation Applied Mathematics for the Life and Social Sciences 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis