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Biophysical Mechanism for Neural Spiking Dynamics


Abstract In the honey bee antennal lobe, uniglomerular projection neurons (uPNs) transiently spike to odor sensory stimuli with odor-specific response latencies, i.e., delays to first spike after odor

stimulation onset. Recent calcium imaging studies show that the spatio-temporal response profile of the activated uPNs are dynamic and changes as a result

of associative conditioning, facilitating odor-detection of learned odors.

Moreover, odor-representation in the antennal lobe undergo reward-mediated plasticity processes that increase response delay variations

in the activated ensemble of uniglomerular projection neurons. Octopamine is necessarily involved in these plasticity processes. Yet, the cellular mechanisms are not

well understood.... (more)
Created Date 2016
Contributor Smith, Adrian Nicholas (Author) / Castillo-Chavez, Carlos (Advisor) / Sinakevitch, Irina T. (Advisor) / Smith, Brian H. (Committee member) / Arizona State University (Publisher)
Subject Applied mathematics
Type Doctoral Dissertation
Extent 54 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Applied Mathematics for the Life and Social Sciences 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis