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Application of Multivalent Interactions for Recognition Imaging and Delivery of Therapeutics

Abstract Multivalency is an important phenomenon that guides numerous biological interactions. It has been utilized in design of therapeutics and drug candidates. Hence, this study attempts to develop analytical tools to study multivalent interactions and design multivalent ligands for drug delivery and therapeutic applications.

Atomic Force Microscopy (AFM) has been envisioned as a means of nanodiagnostics due to its single molecule sensitivity. However, the AFM based recognition imaging lacks a multiplex capacity to detect multiple analytes in a single test. Also there is no user friendly wet chemistry to functionalize AFM tips. Hence, an uncatalyzed Click Chemistry protocol was developed to functionalize AFM tips. For multiplexed recognition... (more)
Created Date 2016
Contributor Manna, Saikat (Author) / Lindsay, Stuart (Advisor) / Zhang, Peiming (Advisor) / Gould, Ian (Committee member) / Stephanopoulos, Nicholas (Committee member) / Arizona State University (Publisher)
Subject Chemistry
Type Doctoral Dissertation
Extent 156 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis