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Analysis of Small Molecule Interactions in Biological Systems: The Study of Potential Treatments for Addiction and Disease


Abstract The ability to manipulate the interaction between small molecules and biological macromolecules towards the study of disease pathogenesis has become a very important part of research towards treatment options for various diseases. The work described here shows both the use of DNA oligonucleotides as carriers for a nicotine hapten small molecule, and the use of microsomes to study the stability of compounds derived to treat mitochondrial diseases.

Nicotine addiction is a worldwide epidemic because nicotine is one of the most widely used addictive substances. It is linked to early death, typically in the form of heart or lung disease. A new vaccine conjugate against nicotine held within a DNA tetrahedron delivery system has been studied. F... (more)
Created Date 2016
Contributor Schmierer, Margaret Louise (Author) / Hecht, Sidney M (Advisor) / Allen, James (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Subject Chemistry / Biochemistry / Analytical chemistry / Addiction / Mitochondrial Disease / Nicotine / Treatments / Vaccine
Type Doctoral Dissertation
Extent 85 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Chemistry 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis