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Compressed Sensing Accelerated Magnetic Resonance Spectroscopic Imaging


Abstract Magnetic resonance spectroscopic imaging (MRSI) is a valuable technique for assessing the in vivo spatial profiles of metabolites like N-acetylaspartate (NAA), creatine, choline, and lactate. Changes in metabolite concentrations can help identify tissue heterogeneity, providing prognostic and diagnostic information to the clinician. The increased uptake of glucose by solid tumors as compared to normal tissues and its conversion to lactate can be exploited for tumor diagnostics, anti-cancer therapy, and in the detection of metastasis. Lactate levels in cancer cells are suggestive of altered metabolism, tumor recurrence, and poor outcome. A dedicated technique like MRSI could contribute to an improved assessment of metabolic abnormalities in ... (more)
Created Date 2016
Contributor Vidya Shankar, Rohini (Author) / Kodibagkar, Vikram D (Advisor) / Pipe, James (Committee member) / Chang, John (Committee member) / Sadleir, Rosalind (Committee member) / Frakes, David (Committee member) / Arizona State University (Publisher)
Subject Biomedical engineering / compressed sensing / fast imaging / magnetic resonance spectroscopic imaging
Type Doctoral Dissertation
Extent 189 pages
Language English
Copyright
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Note Doctoral Dissertation Bioengineering 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis