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Genetic Markers of a Predisposition to Lumbar Disc Degeneration in Young Adults

Abstract Intervertebral Disc Degeneration (IVDD) is a complex phenomenon characterizing the desiccation and structural compromise of the primary joint in the human spine. The intervertebral disc (IVD) serves to connect vertebral bodies, cushion shock, and allow for flexion and extension of the vertebral column. Often presenting in the 4th or 5th decades of life as low back pain, this disease was originally believed to be the result of natural “wear and tear” coupled with repetitive mechanical insult, and as such most studies focus on patients between 40 and 50 years of age. Research over the past two decades, however, has demonstrated that environmental factors have only a modest effect on disc degeneration, with genetic influences playing a much mo... (more)
Created Date 2016
Contributor Fulton, Travis (Author) / Liebig, Juergen (Advisor) / Neisewander, Janet (Committee member) / Theodore, Nicholas (Committee member) / Arizona State University (Publisher)
Subject Biology / Genetics / aggrecan / degenerative disc disease / genetic markers / IVDD / lumbar intervertebral disc degeneration / young adults
Type Masters Thesis
Extent 64 pages
Language English
Reuse Permissions All Rights Reserved
Note Masters Thesis Biology 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis