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Ultrafast Electrons and X-rays as Probe of Biomolecular Dynamics

Abstract The structure-function relation in Biology suggests that every biological molecule has evolved its structure to carry out a specific function. However, for many of these processes (such as those with catalytic activity) the structure of the biomolecule changes during the course of a reaction. Understanding the structure-function relation thus becomes a question of understanding biomolecular dynamics that span a variety of timescales (from electronic rearrangements in the femtoseconds to side-chain alteration in the microseconds and more). This dissertation deals with the study of biomolecular dynamics in the ultrafast timescales (fs-ns) using electron and X-ray probes in both time and frequency domains.

It starts with establishing the lim... (more)
Created Date 2016
Contributor Subramanian, Ganesh (Author) / Spence, John (Advisor) / Rez, Peter (Committee member) / Alford, Terry (Committee member) / Weierstall, Uwe (Committee member) / Kirian, Richard (Committee member) / Arizona State University (Publisher)
Subject Materials Science / Biophysics / Electron Diffraction / Structural Biology / Ultrafast probes / X-ray Spectroscopy
Type Doctoral Dissertation
Extent 223 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Materials Science and Engineering 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis