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Protein Conformational Dynamics In Genomic Analysis


Abstract Proteins are essential for most biological processes that constitute life. The function of a protein is encoded within its 3D folded structure, which is determined by its sequence of amino acids. A variation of a single nucleotide in the DNA during transcription (nSNV) can alter the amino acid sequence (i.e., a mutation in the protein sequence), which can adversely impact protein function and sometimes cause disease. These mutations are the most prevalent form of variations in humans, and each individual genome harbors tens of thousands of nSNVs that can be benign (neutral) or lead to disease. The primary way to assess the impact of nSNVs on function is through evolutionary approaches based on positional amino acid conservation. These appro... (more)
Created Date 2016
Contributor Butler, Brandon Mac (Author) / Ozkan, S. Banu (Advisor) / Vaiana, Sara (Committee member) / Ghirlanda, Giovanna (Committee member) / Ros, Robert (Committee member) / Arizona State University (Publisher)
Subject Biophysics / computational biophysics / disease prediction / precision medicine / protein conformational dynamics / protein evolution / single nucleotide variant
Type Doctoral Dissertation
Extent 148 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Physics 2016
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis