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A biologically active peptide mimetic of N-acetylgalactosamine/galactose


Abstract Background
Glycosylated proteins and lipids are important regulatory factors whose functions can be altered by addition or removal of sugars to the glycan structure. The glycans are recognized by sugar-binding lectins that serve as receptors on the surface of many cells and facilitate initiation of an intracellular signal that changes the properties of the cells. We identified a peptide that mimics the ligand of an N-acetylgalactosamine (GalNAc)-specific lectin and asked whether the peptide would express specific biological activity.
Findings
A 12-mer phage display library was screened with a GalNAc-specific lectin to identify an amino acid sequence that binds to the lectin. Phage particles that were eluted from the lectin with free GalNAc ... (more)
Created Date 2009-02-11
Contributor Eggink, Laura (ASU author) / Hoober, Kenneth (ASU author) / College of Liberal Arts and Sciences / School of Life Sciences
Series BMC RESEARCH NOTES
Type Text
Extent 6 pages
Language English
Identifier DOI: 10.1186/1756-0500-2-23 / ISSN: 1756-0500
Copyright
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Citation Eggink, L. L., & Hoober, J. K. (2009). A biologically active peptide mimetic of N-acetylgalactosamine/galactose. BMC Research Notes, 2(1), 23. doi:10.1186/1756-0500-2-23
Note The electronic version of this article is the complete one and can be found online at: http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-2-23
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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