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Juvenile hormone regulation of Drosophila aging

Abstract Background
Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the hormone’s source. In contrast, little is known about how juvenile hormone affects adult Drosophila melanogaster. Previous work suggests that insulin signaling may modulate Drosophila aging in part through its impact on juvenile hormone titer, but no data yet address whether reduction of juvenile hormone is sufficient to control Drosophila life span. Here we adapt a genetic approach to knock out the corpora allata in adult Drosophila melanogaster and characterize adult life history phenotypes produced by reduction of juvenile hormone. With this system we test potential e... (more)
Created Date 2013-07-17
Contributor Yamamoto, Rochelle (Author) / Bai, Hua (Author) / Dolezal, Adam (ASU author) / Amdam, Gro (ASU author) / Tatar, Marc (Author) / College of Liberal Arts and Sciences / School of Life Sciences
Type Text
Extent 14 pages
Language English
Identifier DOI: 10.1186/1741-7007-11-85 / ISSN: 1741-7007
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Citation Yamamoto, R., Bai, H., Dolezal, A. G., Amdam, G., & Tatar, M. (2013). Juvenile hormone regulation of Drosophila aging. BMC Biology, 11(1), 85. doi:10.1186/1741-7007-11-85
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