Malignant brain tumors affect people of all ages and are the second leading cause of cancer deaths in children. While current treatments are effective and improve survival, there remains a substantial need for more efficacious therapeutic modalities. The ketogenic diet (KD) - a high-fat, low-carbohydrate treatment for medically refractory epilepsy - has been suggested as an alternative strategy to inhibit tumor growth by altering intrinsic metabolism, especially by inducing glycopenia.
Here, we examined the effects of an experimental KD on a mouse model of glioma, and compared patterns of gene expression in tumors vs. normal brain from animals fed either a KD or a standard diet.
Animals received intracranial injec... (more)
|Contributor||Stafford, Phillip (ASU author) / Abdelwahab, Mohammed G. (Author) / Kim, Do Young (Author) / Preul, Mark C. (Author) / Rho, Jong M. (Author) / Scheck, Adrienne C. (Author) / Biodesign Institute / Innovations in Medicine|
|Series||NUTRITION & METABOLISM|
|Identifier||DOI: 10.1186/1743-7075-7-74 / ISSN: 1743-7075|
|Citation||Stafford, P., Abdelwahab, M. G., Kim, D., Preul, M. C., Rho, J. M., & Scheck, A. C. (2010). The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutrition & Metabolism, 7(1), 74. doi:10.1186/1743-7075-7-74|
|Note||The electronic version of this article is the complete one and can be found online at: http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-74|
|Collaborating Institutions||ASU Library|
|Additional Formats||MODS / OAI Dublin Core / RIS|