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The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma


Abstract Background
Malignant brain tumors affect people of all ages and are the second leading cause of cancer deaths in children. While current treatments are effective and improve survival, there remains a substantial need for more efficacious therapeutic modalities. The ketogenic diet (KD) - a high-fat, low-carbohydrate treatment for medically refractory epilepsy - has been suggested as an alternative strategy to inhibit tumor growth by altering intrinsic metabolism, especially by inducing glycopenia.
Methods
Here, we examined the effects of an experimental KD on a mouse model of glioma, and compared patterns of gene expression in tumors vs. normal brain from animals fed either a KD or a standard diet.
Results
Animals received intracranial injec... (more)
Created Date 2010-09-10
Contributor Stafford, Phillip (ASU author) / Abdelwahab, Mohammed G. (Author) / Kim, Do Young (Author) / Preul, Mark C. (Author) / Rho, Jong M. (Author) / Scheck, Adrienne C. (Author) / Biodesign Institute / Innovations in Medicine
Series NUTRITION & METABOLISM
Type Text
Extent 11 pages
Language English
Identifier DOI: 10.1186/1743-7075-7-74 / ISSN: 1743-7075
Rights
Citation Stafford, P., Abdelwahab, M. G., Kim, D., Preul, M. C., Rho, J. M., & Scheck, A. C. (2010). The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutrition & Metabolism, 7(1), 74. doi:10.1186/1743-7075-7-74
Note The electronic version of this article is the complete one and can be found online at: http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-74
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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