Improved Spatial Coverage of High-Temporal Resolution Dynamic Susceptibility Contrast-MRI Through 3D Spiral-Based Acquisition and Parallel Imaging
|Abstract||Dynamic susceptibility contrast MRI (DSC-MRI) is a powerful tool used to quantitatively measure parameters related to blood flow and volume in the brain. The technique is known as a “bolus-tracking” method and relies upon very fast scanning to accurately measure the flow of contrast agent into and out of a region of interest. The need for high temporal resolution to measure contrast agent dynamics limits the spatial coverage of perfusion parameter maps which limits the utility of DSC-perfusion studies in pathologies involving the entire brain. Typical clinical DSC-perfusion studies are capable of acquiring 10-15 slices, generally centered on a known lesion or pathology.
The methods developed in this work improve the spatial coverage of who... (more)
|Contributor||Turley, Dallas (Author) / Pipe, James G (Advisor) / Kodibagkar, Vikram (Advisor) / Frakes, David (Committee member) / Sadleir, Rosalind (Committee member) / Schmainda, Kathleen (Committee member) / Arizona State University (Publisher)|
|Reuse Permissions||All Rights Reserved|
|Note||Doctoral Dissertation Bioengineering 2017|
|Collaborating Institutions||Graduate College / ASU Library|
|Additional Formats||MODS / OAI Dublin Core / RIS|