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Improved Spatial Coverage of High-Temporal Resolution Dynamic Susceptibility Contrast-MRI Through 3D Spiral-Based Acquisition and Parallel Imaging

Abstract Dynamic susceptibility contrast MRI (DSC-MRI) is a powerful tool used to quantitatively measure parameters related to blood flow and volume in the brain. The technique is known as a “bolus-tracking” method and relies upon very fast scanning to accurately measure the flow of contrast agent into and out of a region of interest. The need for high temporal resolution to measure contrast agent dynamics limits the spatial coverage of perfusion parameter maps which limits the utility of DSC-perfusion studies in pathologies involving the entire brain. Typical clinical DSC-perfusion studies are capable of acquiring 10-15 slices, generally centered on a known lesion or pathology.

The methods developed in this work improve the spatial coverage of who... (more)
Created Date 2017
Contributor Turley, Dallas (Author) / Pipe, James G (Advisor) / Kodibagkar, Vikram (Advisor) / Frakes, David (Committee member) / Sadleir, Rosalind (Committee member) / Schmainda, Kathleen (Committee member) / Arizona State University (Publisher)
Subject Medical imaging
Type Doctoral Dissertation
Extent 150 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Bioengineering 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis