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The Effect of Rho Kinase Inhibitors on Alzheimer's Disease


Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease that affects 5.4 million Americans. AD leads to memory loss, changes in behavior, and death. The key hallmarks of the disease are amyloid plaques and tau tangles, consisting of amyloid-β oligomers and hyperphosphorylated tau, respectively.

Rho-associated, coiled-coil-containing protein kinase (ROCK) is an enzyme that plays important roles in neuronal cells including mediating actin organization and dendritic spine morphogenesis. The ROCK inhibitor Fasudil has been shown to increase learning and working memory in aged rats, but another ROCK inhibitor, Y27632, was shown to impair learning and memory. I am interested in exploring how these, and other ROCK inhibitors, may be a... (more)
Created Date 2017
Contributor Turk, Mari Nicole (Author) / Huentelman, Matt (Advisor) / Kusumi, Kenro (Advisor) / Jensen, Kendall (Committee member) / Stabenfeldt, Sarah (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Aging / Alzheimer's disease / Hippocampus / Morris water maze / Mouse / Radial arm water maze
Type Doctoral Dissertation
Extent 149 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Neuroscience 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis