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Tracing the Evolutionary Histories of Leprosy and Tuberculosis using Ancient DNA and Phylogenomics Methods


Abstract Leprosy and tuberculosis are age-old diseases that have tormented mankind and left behind a legacy of fear, mutilation, and social stigmatization. Today, leprosy is considered a Neglected Tropical Disease due to its high prevalence in developing countries, while tuberculosis is highly endemic in developing countries and rapidly re-emerging in several developed countries. In order to eradicate these diseases effectively, it is necessary to understand how they first originated in humans and whether they are prevalent in nonhuman hosts which can serve as a source of zoonotic transmission. This dissertation uses a phylogenomics approach to elucidate the evolutionary histories of the pathogens that cause leprosy and tuberculosis, Mycobacterium l... (more)
Created Date 2017
Contributor Honap, Tanvi Prasad (Author) / Stone, Anne C (Advisor) / Rosenberg, Michael S (Advisor) / Clark-Curtiss, Josephine E (Committee member) / Krause, Johannes (Committee member) / Arizona State University (Publisher)
Subject Biology / Genetics / Ancient DNA / Leprosy / Pathogens / Phylogenetics / Tuberculosis
Type Doctoral Dissertation
Extent 154 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Evolutionary Biology 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis
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Description Appendix_A
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Description Appendix_B
  1205211666_Dissertation_Honap_Appendix_F.xlsx
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Description Appendix_F