Skip to main content

Tracing the Evolutionary Histories of Leprosy and Tuberculosis using Ancient DNA and Phylogenomics Methods

Abstract Leprosy and tuberculosis are age-old diseases that have tormented mankind and left behind a legacy of fear, mutilation, and social stigmatization. Today, leprosy is considered a Neglected Tropical Disease due to its high prevalence in developing countries, while tuberculosis is highly endemic in developing countries and rapidly re-emerging in several developed countries. In order to eradicate these diseases effectively, it is necessary to understand how they first originated in humans and whether they are prevalent in nonhuman hosts which can serve as a source of zoonotic transmission. This dissertation uses a phylogenomics approach to elucidate the evolutionary histories of the pathogens that cause leprosy and tuberculosis, Mycobacterium l... (more)
Created Date 2017
Contributor Honap, Tanvi Prasad (Author) / Stone, Anne C (Advisor) / Rosenberg, Michael S (Advisor) / Clark-Curtiss, Josephine E (Committee member) / Krause, Johannes (Committee member) / Arizona State University (Publisher)
Subject Biology / Genetics / Ancient DNA / Leprosy / Pathogens / Phylogenetics / Tuberculosis
Type Doctoral Dissertation
Extent 154 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Evolutionary Biology 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

  Full Text
4.5 MB application/pdf
Download Count: 143

Description Dissertation/Thesis
38.8 KB application/zip
Download Count: 8

Description Appendix_A
4.1 MB text/plain
Download Count: 12

Description Appendix_B
47.0 KB application/zip
Download Count: 9

Description Appendix_F