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Primate Skeletal Epigenetics: Evolutionary Implications of DNA Methylation Patterns in the Skeletal Tissues of Human and Nonhuman Primates


Abstract Within the primate lineage, skeletal traits that contribute to inter-specific anatomical variation and enable varied niche occupations and forms of locomotion are often described as the result of environmental adaptations. However, skeletal phenotypes are more accurately defined as complex traits, and environmental, genetic, and epigenetic mechanisms, such as DNA methylation which regulates gene expression, all contribute to these phenotypes. Nevertheless, skeletal complexity in relation to epigenetic variation has not been assessed across the primate order. In order to gain a complete understanding of the evolution of skeletal phenotypes across primates, it is necessary to study skeletal epigenetics in primates. This study attempts to fill... (more)
Created Date 2017
Contributor Housman, Genevieve (Author) / Stone, Anne (Advisor) / Quillen, Ellen (Committee member) / Kusumi, Kenro (Committee member) / Stojanowski, Christopher (Committee member) / Arizona State University (Publisher)
Subject Physical anthropology / Genetics / bone / cartilage / DNA methylation / epigenome / evolution / nonhuman primates
Type Doctoral Dissertation
Extent 332 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Anthropology 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


  Full Text
6.5 MB application/pdf
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Description Dissertation/Thesis
  GeneSpecific_HOXD10_Specs.xlsx
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  Probe_Annotation_Filters.zip
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  450K_Baboon_OA_ProbeCorr.xlsx
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  450K_Baboon_OA_Samples.xlsx
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  450K_Baboon_OA.zip
39.6 MB application/zip
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  450K_Baboon_ProbeDist.xlsx
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  EPIC_Baboon_Aging_Compare.xlsx
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  EPIC_Baboon_Aging.zip
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  EPIC_Baboon_Aging_DMPDist.xlsx
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  EPIC_Baboon_Aging_DMPGenes.xlsx
16.6 KB application/zip
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  EPIC_Baboon_Aging_DMP.xlsx
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  EPIC_Baboon_Aging_GO.xlsx
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  EPIC_Baboon_Aging_DMR.xlsx
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  EPIC_Baboon_Aging_KEGG.xlsx
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  EPIC_Baboon_Aging_ProbeCorr.xlsx
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  EPIC_Baboon_Aging_Samples.xlsx
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  EPIC_Baboon_OA.zip
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  EPIC_Baboon_OA_Compare.xlsx
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  EPIC_Baboon_OA_CompareGene.xlsx
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  EPIC_Baboon_OA_DMP.xlsx
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  EPIC_Baboon_OA_DMPDist.xlsx
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  EPIC_Baboon_OA_DMPGenes.xlsx
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  EPIC_Baboon_OA_DMR.xlsx
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  EPIC_Baboon_OA_GO.xlsx
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  EPIC_Baboon_OA_KEGG.xlsx
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  EPIC_Baboon_OA_ProbeCorr.xlsx
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  EPIC_Baboon_OA_Samples.xlsx
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  EPIC_Baboon_ProbeDist.xlsx
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  EPIC_NHP_InterStudy.zip
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  EPIC_NHP_InterStudy_DMPDist.xlsx
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  EPIC_NHP_InterStudy_DMPGene.xlsx
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  EPIC_NHP_InterStudy_DMP.xlsx
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  EPIC_NHP_InterStudy_GO.xlsx
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  EPIC_NHP_InterStudy_KEGG.xlsx
110.7 KB application/zip
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  EPIC_NHP_IntraStudy_Baboon.zip
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  EPIC_NHP_IntraStudy_DMP.xlsx
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  EPIC_NHP_IntraStudy_DMPGene.xlsx
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  EPIC_NHP_IntraStudy_Chimpanzee.zip
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  EPIC_NHP_IntraStudy_Morphology.xlsx
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  EPIC_NHP_IntraStudy_Marmoset.zip
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  EPIC_NHP_IntraStudy_Macaque.zip
32.5 MB application/zip
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  EPIC_NHP_ProbeDist.xlsx
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  EPIC_NHP_Study_ProbeCorr.xlsx
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  EPIC_NHP_IntraStudy_Vervet.zip
32.6 MB application/zip
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  EPIC_NHP_Study_Samples.xlsx
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  GeneSpecific_HOXD10_AlignBS.fas
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  GeneSpecific_HOXD10_AlignReg.fas
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  GeneSpecific_HOXD10_CpG.xlsx
29.6 KB application/zip
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  GeneSpecific_HOXD10_Primers.xlsx
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  GeneSpecific_HOXD10_Sequences.zip
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