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Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery


Abstract Background
Obesity is a disease that is caused by genetic and environmental factors. However, epigenetic mechanisms of obesity are less well known. DNA methylation provides a mechanism whereby environmental factors can influence gene transcription. The aim of our study was to investigate skeletal muscle DNA methylation of sorbin and SH3 domain containing 3 (SORBS3) with weight loss induced by Roux-en-Y gastric bypass (RYGB).
Results
Previously, we had shown increased methylation (5.0 to 24.4%) and decreased gene expression (fold change − 1.9) of SORBS3 with obesity (BMI > 30 kg/m[superscript 2]) compared to lean controls. In the present study, basal muscle biopsies were obtained from seven morbidly obese (BMI > 40 kg/m[superscript 2])... (more)
Created Date 2017-09-02
Contributor Day, Samantha (ASU author) / Garcia, Luis A. (Author) / Coletta, Richard L. (Author) / Campbell, Latoya (ASU author) / Benjamin, Tonya R. (Author) / De Filippis, Elena A. (Author) / Madura, James A. (Author) / Mandarino, Lawrence J. (Author) / Roust, Lori R. (Author) / Coletta, Dawn K. (Author) / College of Liberal Arts and Sciences / School of Life Sciences
Series CLINICAL EPIGENETICS
Type Text
Extent 8 pages
Language English
Identifier DOI: 10.1186/s13148-017-0396-5 / ISSN: 1868-7083
Copyright
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Citation Day, S. E., Garcia, L. A., Coletta, R. L., Campbell, L. E., Benjamin, T. R., Filippis, E. A., . . . Coletta, D. K. (2017). Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery. Clinical Epigenetics, 9(1). doi:10.1186/s13148-017-0396-5
Note The electronic version of this article is the complete one and can be found online at: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-017-0396-5
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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