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The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution


Abstract Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mutation rate of influenza A virus (IAV). Potential synergistic benefits of combining oseltamivir and favipiravir have been demonstrated in animal models of influenza, but the population-level effects of combining the drugs are unknown. In order to elucidate the underlying evolutionary processes at play, we performed genome-wide sequencing of IAV experimental populations subjected to serial passaging in vitro under a combined protocol of oseltamivir and favipiravir. We describe the interplay... (more)
Created Date 2017-07-19
Contributor Ormond, Louise (Author) / Liu, Ping (Author) / Matuszewski, Sebastian (Author) / Renzette, Nicholas (Author) / Bank, Claudia (Author) / Zeldovich, Konstantin (Author) / Bolon, Daniel N. (Author) / Kowalik, Timothy F. (Author) / Finberg, Robert W. (Author) / Jensen, Jeffrey (ASU author) / Wang, Jennifer P. (Author) / College of Liberal Arts and Sciences / School of Life Sciences
Series GENOME BIOLOGY AND EVOLUTION
Type Text
Extent 12 pages
Language English
Identifier DOI: 10.1093/gbe/evx138 / ISSN: 1759-6653
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Citation Ormond, L., Liu, P., Matuszewski, S., Renzette, N., Bank, C., Zeldovich, K., . . . Wang, J. P. (2017). The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution. Genome Biology and Evolution, 9(7), 1913-1924. doi:10.1093/gbe/evx138
Note The final version of this article, as published in Genome Biology and Evolution, can be viewed online at: https://academic.oup.com/gbe/article-lookup/doi/10.1093/gbe/evx138
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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