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Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis


Abstract The metastatic activity of breast carcinomas results from complex genetic changes in epithelial tumor cells and accounts for 90% of deaths in affected patients. Although the invasion of the local lymphatic vessels and veins by malignant breast tumor cells and their subsequent metastasis to the lung, has been recognized, the mechanisms behind the metastatic activity of breast tumor cells to other distal organs and the pathogenesis of metastatic cancer are not well understood. In this study, we utilized derivatives of the well-established and highly metastatic triple negative breast cancer (TNBC) cell line MDA-MB-231 (MDA-231) to study breast tumor metastasis in a mouse model. These MDA-231 derivatives had depleted expression of Kaiso, a POZ-... (more)
Created Date 2017-09-07
Contributor Kwiecien, Jacek M. (Author) / Bassey-Archibong, Blessing I. (Author) / Dabrowski, Wojciech (Author) / Rayner, Lyndsay G. (Author) / Lucas, Alexandra (ASU author) / Daniel, Juliet M. (Author) / Arizona State University. Biodesign Institute
Series PLOS ONE
Type Text
Extent 17 pages
Language English
Identifier DOI: 10.1371/journal.pone.0183883 / ISSN: 1045-3830 / ISSN: 1939-1560
Rights
Citation Kwiecien, J. M., Bassey-Archibong, B. I., Dabrowski, W., Rayner, L. G., Lucas, A. R., & Daniel, J. M. (2017). Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis. Plos One, 12(9). doi:10.1371/journal.pone.0183883
Note The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183883
Collaborating Institutions ASU Libraries
Additional Formats MODS / OAI Dublin Core / RIS


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