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Preclinical Evidence That 5-HT1B Receptor Agonists Show Promise as Medications for Psychostimulant Use Disorders


Abstract Background
5-HT1B receptor agonists enhance cocaine intake during daily self-administration sessions but decrease cocaine intake when tested after prolonged abstinence. We examined if 5-HT1B receptor agonists produce similar abstinence-dependent effects on methamphetamine intake.
Methods
Male rats were trained to self-administer methamphetamine (0.1 mg/kg, i.v.) on low (fixed ratio 5 and variable ratio 5) and high (progressive ratio) effort schedules of reinforcement until intake was stable. Rats were then tested for the effects of the selective 5-HT1B receptor agonist, CP 94,253 (5.6 or 10 mg/kg), or the less selective but clinically available 5-HT1B/1D receptor agonist, zolmitriptan (10 mg/kg), on methamphetamine self-administration both ... (more)
Created Date 2017-04-22
Contributor Garcia, Raul (ASU author) / Cotter, Austin (ASU author) / Leslie, Kenneth (ASU author) / Olive, M. Foster (ASU author) / Neisewander, Janet (ASU author) / College of Liberal Arts and Sciences / School of Life Sciences / Department of Psychology
Series INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Type Text
Extent 10 pages
Language English
Identifier DOI: 10.1093/ijnp/pyx025 / ISSN: 1461-1457 / ISSN: 1469-5111
Copyright
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Citation Garcia, R., Cotter, A. R., Leslie, K., Olive, M. F., & Neisewander, J. L. (2017). Preclinical Evidence That 5-HT1B Receptor Agonists Show Promise as Medications for Psychostimulant Use Disorders. International Journal of Neuropsychopharmacology, 20(8), 644-653. doi:10.1093/ijnp/pyx025
Note The final version of this article, as published in International Journal of Neuropsychopharmacology, can be viewed online at: https://academic.oup.com/ijnp/article-lookup/doi/10.1093/ijnp/pyx025
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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