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Mathematical Model for IL-6-Mediated Tumor Growth, and Targeted Treatment

Abstract Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer

type worldwide, accounts for more than 630,000 new cases and 350,000 deaths

annually. Drug-resistance and tumor recurrence are the most challenging problems

in head and neck cancer treatment. It is hypothesized that a very small fraction

of stem-like cells within HNSCC tumor, called cancer stem cells (CSCs), is

responsible for tumor initiation, progression, resistance and recurrence. It has also

been shown that IL-6 secreted by head and neck tumor-associated endothelial cells

(ECs) enhances the survival, self-renewal and tumorigenic potential of head and

neck CSCs. In this study we will use a mathematical multi-scale model which operates

at the intracellula... (more)
Created Date 2017
Contributor Nazari, Fereshteh (Author) / Jackson, Trachette L. (Advisor) / Jackson, Trachette L. (Committee member) / Castillo-Chavez, Carlos (Committee member) / Towers, Sherry (Committee member) / Kang, Yun (Committee member) / Arizona State University (Publisher)
Subject Applied mathematics
Type Doctoral Dissertation
Extent 199 pages
Language English
Reuse Permissions All Rights Reserved
Note Doctoral Dissertation Applied Mathematics for the Life and Social Sciences 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis