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Characterization of Exosomes In Pediatric Cancer Cells

Abstract Exosomes have been known to secrete an increased amount of miRNA and noncoding genes that are abnormally expressed in various cancer subtypes. Thus, they may be an early marker for pediatric cancer types that are more difficult to diagnosis without invasive techniques, and may also help identify progression of the disease. In the project, six types of pediatric cancer cell lines, along with their extracted exosomes, were analyzed and tested for different monoclonal antibodies through western blot analysis. The genes EWS-FLI1 and FGFR4 were also identified in some cancer cell lines through Reverse-Transcriptase Polymerase Chain Reaction analysis (RT-PCR). The results were indicative of similar protein markers being found in both the originat... (more)
Created Date 2017-12
Contributor Kaur Bhinder, Harsimran (Author) / Lake, Douglas (Thesis Director) / Azorsa, David (Committee Member)
Subject Exosomes / Cancer / Pediatrics / RT-PCR
Series Academic Year 2017-2018
Type Text
Extent 17 pages
Language English
Reuse Permissions All Rights Reserved
Collaborating Institutions Barrett, the Honors College
Additional Formats MODS / OAI Dublin Core / RIS

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