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Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein


Abstract The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is known about the capacity of these adjuvants to modulate the epitope specificity of antibodies directed against antigens. This study characterizes the role of LT and its non-toxic B subunit (LTB) in the modulation of antibody responses to a coadministered antigen, the dengue virus (DENV) envelope glycoprotein domain III (EDIII), which binds to surface receptors and mediates virus entry into host cells. In contrast to non-adjuvanted ... (more)
Created Date 2017-09-25
Contributor Lina Nascimento Fabris Maeda, Denicar (Author) / Tavares Batista, Milene (ASU author) / Ramos Pereira, Lennon (Author) / de Jesus Cintra, Mariana (Author) / Henrique Amorim, Jaime (Author) / Mathias-Santos, Camila (Author) / Araujo Pereira, Sara (Author) / Beatriz Boscardin, Silvia (Author) / dos Ramos Silva, Sandriana (Author) / Faquim-Mauro, Eliana L. (Author) / Barbosa Silveira, Vanessa (Author) / Bruna Leal Oliveira, Danielle (Author) / Johnston, Stephen (ASU author) / Carlos de Souza Ferreira, Luis (Author) / Falcao Rodrigues, Juliana (Author) / Biodesign Institute / Innovations in Medicine
Series FRONTIERS IN IMMUNOLOGY
Type Text
Extent 13 pages
Language English
Identifier DOI: 10.3389/fimmu.2017.01175 / ISSN: 1664-3224
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Citation Maeda, D. L., Batista, M. T., Pereira, L. R., Cintra, M. D., Amorim, J. H., Mathias-Santos, C., . . . Rodrigues, J. F. (2017). Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein. Frontiers in Immunology, 8. doi:10.3389/fimmu.2017.01175
Note View the article as published at https://www.frontiersin.org/articles/10.3389/fimmu.2017.01175/full
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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