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Blood Pressure Control in Aging Predicts Cerebral Atrophy Related to Small-Vessel White Matter Lesions


Abstract Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship. Using a case-control design matching for age, gender, and educational attainment we selected 64 participants with normal blood pressure, controlled hypertension or uncontrolled hypertension from the Northern Manhattan ... (more)
Created Date 2017-05-15
Contributor Kern, Kyle C. (Author) / Wright, Clinton B. (Author) / Bergfield, Kaitlin L. (Author) / Fitzhugh, Megan C. (Author) / Chen, Kewei (ASU author) / Moeller, James R. (Author) / Nabizadeh, Nooshin (Author) / Elkind, Mitchell S. V. (Author) / Sacco, Ralph L. (Author) / Stern, Yaakov (Author) / DeCarli, Charles S. (Author) / Alexander, Gene E. (Author) / Ira A. Fulton Schools of Engineering / School of Computing, Informatics and Decision Systems Engineering / College of Liberal Arts and Sciences / School of Mathematical and Statistical Sciences
Series FRONTIERS IN AGING NEUROSCIENCE
Type Text
Extent 10 pages
Language English
Identifier DOI: 10.3389/fnagi.2017.00132 / ISSN: 1663-4365
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Citation Kern, K. C., Wright, C. B., Bergfield, K. L., Fitzhugh, M. C., Chen, K., Moeller, J. R., . . . Alexander, G. E. (2017). Blood Pressure Control in Aging Predicts Cerebral Atrophy Related to Small-Vessel White Matter Lesions. Frontiers in Aging Neuroscience, 9. doi:10.3389/fnagi.2017.00132
Note View the article as published at https://www.frontiersin.org/articles/10.3389/fnagi.2017.00132/full
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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