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A chemically defined substrate for the expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells


Abstract Due to the limitation of current pharmacological therapeutic strategies, stem cell therapies have emerged as a viable option for treating many incurable neurological disorders. Specifically, human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs), a multipotent cell population that is capable of near indefinite expansion and subsequent differentiation into the various cell types that comprise the central nervous system (CNS), could provide an unlimited source of cells for such cell-based therapies. However the clinical application of these cells will require (i) defined, xeno-free conditions for their expansion and neuronal differentiation and (ii) scalable culture systems that enable their expansion and neuronal differen... (more)
Created Date 2015-05-13
Contributor Tsai, Yihuan (ASU author) / Cutts, Joshua (ASU author) / Kimura, Azuma (ASU author) / Varun, Divya (ASU author) / Brafman, David (ASU author) / Ira A. Fulton Schools of Engineering / School of Biomedical and Health Systems Engineering
Series STEM CELL RESEARCH
Type Text
Extent 13 pages
Language English
Identifier DOI: 10.1016/j.scr.2015.05.002 / ISSN: 1873-5061 / ISSN: 1876-7753
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Citation Tsai, Y., Cutts, J., Kimura, A., Varun, D., & Brafman, D. A. (2015). A chemically defined substrate for the expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells. Stem Cell Research, 15(1), 75-87. doi:10.1016/j.scr.2015.05.002
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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