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Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing


Abstract Alpha herpesvirus genomes encode the capacity to establish quiescent infections (i.e. latency) in the peripheral nervous system for the life of their hosts. Multiple times during latency, viral genomes can reactivate to start a productive infection, enabling spread of progeny virions to other hosts. Replication of alpha herpesviruses is well studied in cultured cells and many aspects of productive replication have been identified. However, many questions remain concerning how a productive or a quiescent infection is established. While infections in vivo often result in latency, infections of dissociated neuronal cultures in vitro result in a productive infection unless lytic viral replication is suppressed by DNA polymerase inhibitors or in... (more)
Created Date 2017-10-26
Contributor Koyuncu, Orkide O. (Author) / MacGibeny, Margaret A. (Author) / Hogue, Ian (ASU author) / Enquist, Lynn W. (Author) / College of Liberal Arts and Sciences / School of Life Sciences
Series PLOS PATHOGENS
Type Text
Extent 22 pages
Language English
Identifier DOI: 10.1371/journal.ppat.1006608 / ISSN: 1553-7366 / ISSN: 1553-7374
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Citation Koyuncu, O. O., Macgibeny, M. A., Hogue, I. B., & Enquist, L. W. (2017). Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing. PLOS Pathogens, 13(10). doi:10.1371/journal.ppat.1006608
Note The article is published at http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006608
Collaborating Institutions ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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