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Hydrogel Nanosensors for Colorimetric Detection and Dosimetry in Proton Beam Radiotherapy


Abstract Proton beam therapy (PBT) is a state-of-the-art radiotherapy treatment approach that uses focused proton beams for tumor ablation. A key advantage of this approach over conventional photon radiotherapy (XRT) is the unique dose deposition characteristics of protons, resulting in superior healthy tissue sparing. This results in fewer unwanted side effects and improved outcomes for patients. Current available dosimeters are intrinsic, complex and expensive; hence cannot be used to determine the dose delivered to the tumor routinely. Here, we report a hydrogel based plasmonic nanosensor for measurements of clinical doses in ranges between 2-4 GyRBE. In this nanosensor, gold ions, encapsulated in a hydrogel, are reduced to gold nanoparticles fol... (more)
Created Date 2017
Contributor Inamdar, Sahil (Author) / Rege, Kaushal (Advisor) / Anand, Aman (Committee member) / Nannenga, Brent (Committee member) / Arizona State University (Publisher)
Subject Nanotechnology / Chemical engineering / Colorimetric / Dosimetry / Gold Nanoparticles / Hydrogel / Protons / Sensor
Type Masters Thesis
Extent 49 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note Masters Thesis Chemical Engineering 2017
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis